In the face of deepening social and ecological crises, design is emerging as a vital domain of praxis that engages these crises by imagining and organizing alternative life worlds. This confers upon design/ing an ineluctable ontological-political dimension. This lecture outlines the constructive reorientation of design as a praxis meant to heal the web of life, and describes the early stages of application of what we are calling “autonomous transition design” in the Cauca River Valley ...